Effect of hypoxia on drug metabolizing enzymes and transporters and the role of microRNA
10.16438/j.0513-4870.2020-0964
- VernacularTitle:microRNA介导低氧对药物代谢酶和转运体的调控
- Author:
Ya-bin DUAN
1
;
Jun-bo ZHU
1
;
Jian-xin YANG
1
;
Xiang-yang LI
1
,
2
Author Information
1. Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
2. State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China
- Publication Type:Research Article
- Keywords:
miRNA;
hypoxia;
rug metabolizing enzyme;
rug transporter
- From:
Acta Pharmaceutica Sinica
2021;56(1):50-60
- CountryChina
- Language:Chinese
-
Abstract:
The function of circulatory system, nervous system and endocrine system is significantly changed in hypoxic environments. These changes affect the absorption, distribution, metabolism, and excretion of drugs in the body. Drug metabolizing enzymes and transporters are the main factors affecting drug metabolism; microRNA (miRNA) can act directly on drug metabolizing enzymes and transporters and can regulate their genes through hypoxia-inducible factor, inflammatory cytokines, and nuclear receptors. This article reviews the effect of hypoxia on drug metabolizing enzymes and transporters and the mechanisms by which miRNA modulates these proteins and their expression during hypoxia.
