Progress in understanding hepatic fibrosis and renal fibrosis based on the gut-liver-kidney axis

Ming-liang Wang; Yong-fang Ding; Xin Yin; Jiu-zhen Shao; Zi-rui Zhuang; Ting Zhang; Peng-liang SU; Yun-ru Peng

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Progress in understanding hepatic fibrosis and renal fibrosis based on the gut-liver-kidney axis

VernacularTitle:基于肠-肝-肾轴的肝纤维化与肾纤维化研究进展
Author: Ming-liang WANG ^{1
,

2} ; Yong-fang DING ^{1
,

2} ; Xin YIN ^{1
,

2} ; Jiu-zhen SHAO ^{1
,

2} ; Zi-rui ZHUANG ^{1
,

2} ; Ting ZHANG ^{1
,

2} ; Peng-liang SU ^{1
,

2} ; Yun-ru PENG ^{1
,

2}
Author Information

1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
2. Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China
Publication Type:Research Article
Keywords: fibrosis; liver-kidney axis; gut-liver axis; gut-kidney axis; gut-liver-kidney axis
From: Acta Pharmaceutica Sinica 2021;56(1):9-20
CountryChina
Language:Chinese
Abstract: Fibrosis is a pathological process of abnormal hyperplasia and excessive deposition of extracellular matrix during the process of repair after tissue and organ damage. Injury/inflammation caused by variously chronic diseases is a major trigger for fibrogenesis. Fibrosis of the liver and kidney is a common organ fibrosis. Recently, the intestinal microbiota has been shown to be extensively involved in the development of liver and kidney diseases, which may follow from changes in the intestinal microbial composition and intestinal integrity. This promotes the development of liver and/or kidney fibrosis through endocrine, cell signaling and other pathways. This paper reviews the research progress in understanding liver fibrosis and kidney fibrosis based on the gut-liver-kidney axis, which may be helpful for providing new strategies and theoretical basis for the diagnosis and treatment of hepatic and renal fibrosis.