Regulatory function of enhancer of zeste homolog 2 in tumorigenesis
10.3760/cma.j.cn115355-20190916-00418
- VernacularTitle:zeste基因增强子同源物2在肿瘤发生中的调控作用
- Author:
Jia YAO
1
;
Feng ZOU
;
Mengjia XIE
;
Tiejun ZHAO
Author Information
1. 浙江师范大学化学与生命科学学院，浙江 金华 321004
- From:
Cancer Research and Clinic
2020;32(11):801-803
- CountryChina
- Language:Chinese
-
Abstract:
Enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of polycomb repressive complex 2 (PRC2). It acts as a histone methylation transferase and plays a key role in oncogenesis, development, metastasis, and drug tolerance. Studies have found that the expression of EZH2 is regulated by a variety of carcinogenic transcription factors, anti-cancer microRNA, tumor-related non-coding RNA and post-translational modifications. Moreover, the effect of EZH2 in silencing target genes is mainly through trimethylation of histone H3 at lysine 27 (H3K27me3). This article summarizes the main regulatory roles and functions of EZH2 in tumorigenesis, and reviews the progress of target therapies based on EZH2.
