Progress of genomics and targeted therapy in osteosarcoma
10.3760/cma.j.cn115355-20191013-00457
- VernacularTitle:骨肉瘤的基因组学及靶向治疗研究进展
- Author:
Jingyu HOU
1
;
Chuchu WANG
;
Weitao YAO
Author Information
1. 河南省肿瘤医院骨与软组织肿瘤科，郑州 450008
- From:
Cancer Research and Clinic
2020;32(9):658-662
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma is a highly malignant bone tumor that predominantly affects children and adolescents. Standard chemotherapy currently used is usually poor, with a lower survival rate of patients with recurrence or metastasis. And it is necessary to find precise targeted therapy drugs from a genic perspective. This paper reviews the progress of genome research on germline mutation and somatic mutation of osteosarcoma in recent years, summarizes mutations and pathways that are closely related to osteosarcoma and can reflect the characteristics of osteosarcoma in order to provide a hope for the next generation of molecular targeted therapy.
