Correlation of body mass index, blood lipid, serum leptin and adiponectin with papillary thyroid carcinoma
10.3760/cma.j.cn115355-20190709-00302
- VernacularTitle:体质量指数、血脂、血清瘦素和脂联素与甲状腺乳头状癌发生的相关性
- Author:
Huan WANG
1
;
Yang LI
;
Tingting LOU
;
Xiangpeng PANG
;
Yan LI
;
Hui CHI
;
Cuicui MA
;
Ruifang GUO
;
Yahang LIU
Author Information
1. 内蒙古自治区人民医院临床营养中心，呼和浩特 010017
- From:
Cancer Research and Clinic
2020;32(7):481-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of body mass index (BMI), blood lipid, serum leptin, adiponectin with papillary thyroid carcinoma.Methods:A total of 120 patients including 40 cases of papillary thyroid carcinoma (papillary thyroid carcinoma group), 40 cases of nodular goiter (nodular goiter group) and 40 cases diagnosed without thyroid diseases or other metabolic diseases during the corresponding period (the control group) in Inner Mongolia People's Hospital from April 2015 to January 2016 were enrolled. The BMI of all subjects was calculated. The levels of blood lipid, serum leptin and adiponectin were detected.Results:The number of females was more than that of males in nodular goiter group and papillary thyroid carcinoma group, and the difference in gender distribution of three groups was statistically significant (χ 2 = 19.024, P < 0.01). The level of BMI, leptin, triglyceride and total cholesterol of papillary thyroid carcinoma group was higher than that of the control group [(24.86±3.26) kg/m 2 vs. (20.79±2.15) kg/m 2, (0.68±0.07) ng/ml vs. (0.61±0.39) ng/ml, (1.42±0.53) mmol/L vs. (1.05±0.36) mmol/L, (4.76±0.57) mmol/L vs.(4.28±0.46) mmol/L], and the differences were statistically significant ( t values were 4.302, 3.296, 1.993 and 2.177, respectively, all P < 0.05). The level of total cholesterol and low-density lipoprotein [(4.97±0.55) mmol/L, (2.72±0.58) mmol/L] in the nodular goiter group was higher than that in the control group [(4.28±0.46) mmol/L, (2.18±0.69) mmol/L], and the differences were statistically significant ( t values were 2.954 and 2.148, respectively; all P < 0.05). The level of adiponectin [(4.21±0.34) ng/ml, (4.30±0.27) ng/ml] in papillary thyroid carcinoma and nodular goiter group was lower than that in the control group [(4.87±0.27) ng/ml], and the differences were statistically significant ( t values were 7.631 and 7.416, respectively; all P < 0.05). Conclusion:The increase of BMI, triglyceride, total cholesterol, serum leptin and the decrease of serum adiponectin may be related to the occurrence of papillary thyroid carcinoma.
