Progress of relationship between autophagy and hepatocellular carcinoma
10.3760/cma.j.cn115355-20190617-00253
- VernacularTitle:自噬与肝细胞癌关系的研究进展
- Author:
Bolan ZHU
1
;
Xiaojuan YANG
;
Yu ZHANG
;
Ling HUI
;
Xiaohui YU
Author Information
1. 解放军联勤保障部队第九四○医院消化内科，兰州 730050
- From:
Cancer Research and Clinic
2020;32(7):521-524
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with quick disease progression and poor prognosis. The pathogenesis is extremely complex, involving genetic mutations, abnormal activation of signal pathways, and epigenetic changes. Autophagy is a basic physiological phenomenon of maintaining internal environment stability and promoting cell survival when cell stress occurs, which plays an important role in the occurrence, development and prognosis of various tumors including HCC. Autophagy can participate in the formation and progress of HCC through the above molecular mechanisms. This paper reviews the progress of relationship between autophagy and HCC.
