Significance of microsatellite instability for the prognosis and efficacy prediction in gastric cancer
10.3760/cma.j.cn115355-20190623-00265
- VernacularTitle:微卫星不稳定性在胃癌预后及疗效预测中的意义
- Author:
Linghua MENG
1
;
Haitao WU
;
Tingting LIANG
;
Chang WANG
Author Information
1. 吉林大学第一医院肿瘤中心，长春 130021
- From:
Cancer Research and Clinic
2020;32(3):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Microsatellite instability (MSI) is caused by the deficiency of DNA mismatch repair (MMR) protein, which is closely related to the occurrence, development, prognosis and efficacy prediction of various tumors. MSI-high (MSI-H) and mismatch repair protein deficiency (dMMR) might be a predictor factor for the good prognosis of patients with gastric cancer, and a negative predictor factor for the chemotherapy efficacy of resectable gastric cancer. MSI-H/dMMR can be used as a marker for predicting the effective treatment outcome of immune checkpoint inhibitors in advanced gastric cancer, however, the predictive role in palliative chemotherapy of advanced gastric cancer is still unclear. This paper reviews the progress of the association of MSI/MMR with prognosis and efficacy prediction in gastric cancer.
