Progress of the relationship between high mobility group protein A2 and tumors
10.3760/cma.j.cn115355-20190618-00256
- VernacularTitle:高迁移率族蛋白A2与肿瘤关系的研究进展
- Author:
Kai LI
1
;
Qizhong FU
;
Ying LIU
Author Information
1. 大连大学附属中山医院泌尿外科 116001
- From:
Cancer Research and Clinic
2020;32(3):202-205
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group protein A2 (HMGA2) is a non-histone protein that does not have transcriptional activity by itself, but it changes its structure by binding to chromatin, which in turn regulates the transcription of other genes, thereby promoting tumor invasion and metastasis. The related RNA gene can regulate the role of HMGA2 in tumors, and the invasiveness of tumors is closely related to epithelial-mesenchymal transition (EMT), which can treat the related tumors by targeting HMGA2 gene. This article reviews the progress of the relationship between HMGA2 and tumors.
