Progress of the anoikis effector bcl-2 inhibitor of transcription 1
10.3760/cma.j.issn.1006-9801.2020.02.015
- VernacularTitle:失巢凋亡效应分子bcl-2转录抑制因子1的研究进展
- Author:
Jialing LIU
1
;
Linsheng HUANG
;
Xingyu YE
;
Jie ZHOU
;
Fei LI
Author Information
1. 湖北医药学院药学院，十堰 442000
- From:
Cancer Research and Clinic
2020;32(2):133-136
- CountryChina
- Language:Chinese
-
Abstract:
bcl-2 inhibitor of transcription 1 (Bit1) is an anoikis effector that can play a role of caspase-independent apoptosis by down-regulating bcl-2 expression. Previous studies have found that Bit1 affects cell survival and apoptosis through Erk and FAK-PI3K-Akt-NF-κB pathways. It is worth noting that the expression of Bit1 has shown the obvious tumor specificity in different tumors, and it is closely related to TNM stage, differentiation and prognosis of the tumor. This review summarizes the expression, main mechanism, and significance of Bit1 in different tumors.
