Heterotopic Heart Transplantation in the Rat Model.
- Author:
Won Sang JUNG
1
;
Yang Bin JUN
;
Sun Ho JEON
;
Hyuck KIM
;
Churl Bum LEE
;
Young Hak KIM
;
Heng Ok JEE
;
Jung Kook SUH
;
Goo KONG
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Hanyang University Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Heart transplantation;
Allograft;
Immunosuppression
- MeSH:
Allografts;
Animals;
Aorta;
Aorta, Abdominal;
Cyclosporine;
Heart Transplantation*;
Heart*;
Hemorrhage;
Immunosuppression;
Leg;
Models, Animal*;
Nylons;
Paralysis;
Pulmonary Artery;
Rats*;
Silk;
Suture Techniques;
Sutures;
Vena Cava, Inferior
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
1998;31(5):531-535
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In 1964, Abbott and Colleagues published the world's first heterotopic heart transplantation technique in the rat. Their method established circulation by end-to-end anastomoses of the graft's aorta and pulmonary artery to the recipient's abdominal aorta and Inferior Vena Cava (IVC), respectively. In 1966, Tomita et al altered Abbott's technique by employing end-to-side rather than end-to-end anastomoses, thus eliminating the hind leg paralysis that sometimes resulted from Abbott's technique. In order to prevent postsuture hemorrhage (since 7-0 silk suture was the finest available at that time), Tomita's aortic anastomosis was done with double up-and-down continuous suture technique. A single layer continuous anstomosis effected the pulmonary artery-IVC anastomosis. The availability of Nylon monofilament suture made it possible for Ono and Lindsey to use a single layer suture technique for the aortic end-to-side anastomosis in their modified rat heart transplantation. We observed survival time between control group and Immunosuppression (Cyclosporine administration, 10mg/Kgx4 times postoperatively) group after heterotopic heart transplantation in the rat model. The cyclosporine adminstration group survived longer than the control group, thus we concluded that cyclosporine was based on Immunosuppressive drugs.
