Expression of Toll-like receptor 7/9 and myeloid differentiation factor 88 in skin lesions with vitiligo and their clinical significance
10.3760/cma.j.issn.1671-0290.2020.02.022
- VernacularTitle:白癜风患者皮损中Toll样受体7和9及髓样分化因子88的表达及临床意义
- Author:
Yaping TANG
1
;
Zhenjie LI
;
Shujuan ZHANG
;
Yangqi LI
;
Yumei LIU
;
Huilan ZHU
Author Information
1. 广州市皮肤病防治所 510095
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2020;26(2):152-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the differential expression of Toll-like receptor 7/9 and myeloid differentiation factor 88 (MyD88) in skin lesions between patients with vitiligo and healthy individuals as well as their clinical significance.Methods:We collected vitiligo patients in the Guangzhou Institute of Dermatology and Venerology from June 2016 to June 2018. There were 24 vitiligo patients, 12 males and 12 females, aged 5 to 65 (28.75±13.12) years, with medical history of 14 days to 20 years. The expression levels of TLR7/9 and MyD88 in skin lesions were determined from 24 patients with vitiligo and 20 healthy controls by immunohistochemistry.Results:The expression levels of TLR7 and MyD88 in skin lesions were significantly higher in patients with vitiligo than that in the controls, and the difference was statistically significant. The expression level of TLR9 in skin lesions was significantly higher in patients with vitiligo than that in the controls, while no significant difference was observed between the two groups.Conclusions:The expression level of TLR7 and TLR9 is elevated in skin lesions from patients with vitiligo. The abnormal expression level of TLR7 and TLR9 possibly participates in the pathogenesis of vitiligo.
