Expression of angiopoietin-1 during scar strophying
10.3760/cma.j.issn.1671-0290.2020.01.017
- VernacularTitle:瘢痕成熟过程中血管生成素1的表达
- Author:
Zihan WU
1
;
Gaofeng LI
Author Information
1. 吉首大学第一附属医院湘西自治州人民医院烧伤整形科
- Keywords:
Cicatrix;
Angiopoietin-1;
Rabbits;
Pathology;
Models animal
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2020;26(1):67-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of angiopoietin 1 in scar during the scar strophying.Methods The rabbit ear scar model was established in the same position of each ear ventral center skin regardless of gender.The weight of each rabbit was greater than 2.0 kg weight.The scars were collected at weeks 1,2,4,8,and 12.After 12 weeks of scar tissue samples were collected,together with normal skin tissues in the rabbit ear ventral normal skin.The tissues were preseved in 10％ formalin liquid and cryopreserved in liquid nitrogen,respectively.The general form of scar tissues and the expression of Ang-1 in scar were investigated by hematoxylin and eosin staining and Western-blot.Results The expression of Ang-1 increased gradually,and the highest at 2 week after epithelial change as (0.29±0.11),then decreased gradually,and the lowset at week 12 as (0.00± 0.00),which was close to normal skin expression as (0.05±0.01) (P＜0.05).Conclusions Ang-1 may play an important role during the scar atrophying.
