Research progress of small nucleolar RNAs in malignancy
10.3760/cma.j.cn114452-20200404-00361
- VernacularTitle:核仁小RNA在恶性肿瘤中的研究进展
- Author:
Jing CHEN
1
;
Minqi GU
;
Xudong WANG
Author Information
1. 南通大学医学院2017级，南通 226000
- From:
Chinese Journal of Laboratory Medicine
2020;43(10):1050-1054
- CountryChina
- Language:Chinese
-
Abstract:
Small nucleolar RNAs(snoRNAs) constitute a large group of non-coding RNAs. Canonical snoRNAs contain C/D box and H/ACA box types, with the length of 60-300 nucleotides. They are predominantly engaged in 2′-O-methylation or pseudouridylation of ribosomal RNAs. Mounting evidence supported that snoRNAs were a kind of detectable modulators affecting multiple cell behavior and eventually triggered tumorigenesis. The aberration of snoRNAs could regulate cancer-related signal pathways, expedite degradation of p53 protein and induce self-renewal. Herein, the snoRNAs′ structure and the latest progress of snoRNAs research in malignancy were briefly summarized, hoping to provide a new idea for the discovery of effective therapeutic targets and promising tumor prognosis markers.
