The application of free nucleic acid methylation in accurate diagnosis and treatment of tumor
10.3760/cma.j.cn114452-20191213-00728
- VernacularTitle:游离核酸甲基化检测在肿瘤精准诊疗中的应用
- Author:
Zujun SUN
1
;
Dong LI
Author Information
1. 同济大学附属同济医院检验科，上海 200065
- From:
Chinese Journal of Laboratory Medicine
2020;43(7):707-711
- CountryChina
- Language:Chinese
-
Abstract:
It is one of the most important forms of nucleic acid methylation in gene epigenetic modification and the most common driving molecular event in tumors. Detection of the free form nucleic acid can not only assist in early diagnosis and prognosis of tumors, but also avoid the problems of invasion and tumor heterogeneity caused by traditional tumor biopsy methods. In the present paper, the application status of free nucleic acid methylation detection in tumor diagnosis was reviewed, the challenges faced by free nucleic acid methylation detection were analyzed, and prospect of its clinical application was prospected.
