Application of molecular diagnostic technology in detection of antimicrobial resistance
10.3760/cma.j.cn114452-20200306-00190
- VernacularTitle:分子诊断技术在细菌耐药性检测中的应用
- Author:
Xiaofei JIANG
1
;
Yuxing NI
Author Information
1. 复旦大学附属华山医院检验科，上海 200040
- From:
Chinese Journal of Laboratory Medicine
2020;43(7):702-706
- CountryChina
- Language:Chinese
-
Abstract:
Antimicrobial resistance is a serious problem for anti-infective treatment. Molecular technology can quickly, sensitively and accurately detect the mechanism of drug resistance of bacteria, improving the efficacy of anti-infection treatment and the level of infection control. The construction of quality assurance system is a guarantee for the effective application of molecular diagnostic technology in the detection of bacterial resistance. However, due to the complex mechanism of drug resistance, coupled with genetic mutations and other factors, there are problems such as false negatives, false positives, and inconsistency between mechanisms and phenotypes, there are certain restrictions on the application of molecular detection technology. With the development of molecular technology and deepening of people′s understanding of the drug resistance mechanism, the application of molecular diagnostic technology in the detection of bacterial resistance will be more widespread.
