Developments of apolipoprotein M-Sphingosine-1-phosphate in diseases
10.3760/cma.j.cn114452-20191213-00726
- VernacularTitle:载脂蛋白M-1磷酸鞘氨醇与疾病关系的研究进展
- Author:
Zhiyang CHEN
1
;
Jiali WU
;
Weimin WU
;
Min HU
Author Information
1. 中南大学湘雅二医院检验医学科，长沙 410011
- From:
Chinese Journal of Laboratory Medicine
2020;43(5):597-602
- CountryChina
- Language:Chinese
-
Abstract:
Apolipoprotein M (apoM), a member of apolipoprotein family, is primarily combined to high density lipoprotein (HDL) in plasma. The study of apoM developed into a new period since it was discovered as the major carrier of Sphingosine-1-phosphate (S1P) in circulation. apoM-S1P regulates diverse downstream signaling pathways mainly by binding to and activating specific cell-surface receptors. Being aware of the functions of apoM-S1P in different diseases helps us to explore the pathogenesis of diseases and casts new lights on its precaution and treatment. The relationship between apoM-S1P axis and diseases is reviewed below.
