Research status of nicotine-aggravating the choroidal neovascularization formation in wet age-related macular degeneration
10.3760/cma.j.cn511434-20180704-00226
- VernacularTitle:尼古丁加重渗出型老年性黄斑变性脉络膜新生血管形成的研究现状
- Author:
Yajun GONG
1
;
Kunbei LAI
;
Chenjin JIN
Author Information
1. 中山大学中山眼科中心 眼科学国家重点实验室，广州 510060
- From:
Chinese Journal of Ocular Fundus Diseases
2020;36(4):319-322
- CountryChina
- Language:Chinese
-
Abstract:
Choroidal neovascularization is the leading causes of central vision loss in wet age-related macular degeneration (wAMD) patients. Smoking not only aggravates the incidence and severity of the choroidal neovascularization of wAMD, but also affects the clinical treatment, making the prognosis worse. Nicotine, as an important harmful substance in tobacco, is an easily addictive and highly toxic alkaloid. Animal experiments and clinical studies have confirmed that nicotine can aggravate wAMD by mediating angiogenesis through nicotinic acetylcholine receptor, bone marrow blasts, inflammation, complement system, etc. Therefore, in order to early take appropriate intervention measures to prevent and delay the development, we should actively explore the exact pathogenesis by which nicotine aggravates the choroidal neovascularization.
