Research progress of cytokines in vitreous of diabetic retinopathy

VernacularTitle:玻璃体液中细胞因子表达水平与糖尿病视网膜病变发病关系的研究进展
Author: Dejia WEN ¹ ; Xinjun REN ; Chuanzhen ZHENG ; Ye HE ; Qiong WANG ; Yaru HONG ; Xiaorong LI
Author Information

1. 天津医科大学眼科医院　天津医科大学眼科研究所　天津医科大学眼视光学院　300384
From: Chinese Journal of Ocular Fundus Diseases 2020;36(2):151-155
CountryChina
Language:Chinese
Abstract: Blood-retina barrier destruction, nerve injury, formation of neovascularization and fibroblast proliferation membrane are important pathological changes of DR, which are related to the combined effects of various vitreous cytokines. VEGF is mainly involved in increasing retinal vascular permeability and inducing neovascularization. Pigment epithelium derived factor is vital reducing vascular permeability and neuroprotection; IL plays a key role in mediating inflammatory response. TNF-α is related to inflammation, which is significantly up-regulated by hypoxia. TGF-β is an important cytokine regulating cell proliferation and differentiation. Connective tissue growth factor can promote the growth, migration and adhesion of endothelial cell. In addition, many other molecular mechanisms have not been fully elucidated, and further study on the molecular mechanism of DR is urgent. With the further study of molecular mechanism, the early intervention and targeted treatment of DR will be more effective.