Research status of antisense non-coding RNA in INK4 locus in long-chain non-coding RNA in diabetic retinopathy
10.3760/cma.j.issn.1005-1015.2020.01.019
- VernacularTitle:长链非编码RNA中INK4基因座中反义非编码RNA在糖尿病视网膜病变中的研究现状
- Author:
Shuze CHEN
1
;
Zhengtong YU
;
Zihong WANG
;
Xiaoqian LIANG
;
Huimin ZHONG
;
Min FU
Author Information
1. 南方医科大学第二临床医学院
- Keywords:
Diabetic retinopathy;
Review;
Long-chain non-coding RNA;
Antisense non-coding RNA in the ink4 locus
- From:
Chinese Journal of Ocular Fundus Diseases
2020;36(1):78-81
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of diabetic retinopathy (DR) is complex.Antisense non-coding RNA (ANRIL) in the INK4 locus in long-chain non-coding RNA (lncRNA) is closely related to cell proliferation,differentiation,and individual development.It plays an important role in the dysplasia of retinal vascular endothelial cells and is a new field in the study of the pathogenesis of DR.According to the researches at present,ANRIL may plays its role in the occurrence and development of DR through the signal pathway of nuclear factor-κB and ROS/polyadenylation diphosphate ribose polymerase,and interact with p300,miR-200b,and EZH2 to regulating the expression and function of VEGF.Specific blocking ANRIL and its related pathwaysmay become a new target in the treatment of DR.
