Influential factors of hypoplastic aortic arch caused by neural crest cells
10.3760/cma.j.cn112434-20190825-00282
- VernacularTitle:神经嵴细胞导致主动脉弓发育不良的影响因素
- Author:
Jiajun YE
1
;
Xin JIN
Author Information
1. 重庆医科大学附属儿童医院儿科学院 400013
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2020;36(8):468-471
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac neural crest cells(CNCCs) are a special subgroup of neural crest cells that originate from the dorsal side of the ectodermal neural tube. During embryonic development, they are a pluripotent stem cell group that can migrate to the periphery and differentiate into many types of cells. They are essential for proper development of heart and outflow tract(OFT). Hypoplastic aortic arch(HAA) is a type of congenital heart malformation caused by abnormal development of the ventricular outflow tract in the embryonic period, and often combined with other cardiac malformations. It is a common and poor prognosis after birth in complex congenital heart disease, which seriously endangers children's health. There is a significant correlation between abnormal development of CNCCs and HAA. Although the influencing factors are still unclear, related experiments have screened out relevant genetic and environmental factors. Discussing the mechanism of its involvement in the development of cardiac outflow tract is helpful to understand the pathogenesis of HAA and promote the progress of treatment methods. This article reviews the genetic and environmental factors affecting the development of CNCCs and their correlation with HAA.
