Subclinical hypothyroidism increases the risk of respiratory tract infection in female patients after coronary artery bypass grafting
10.3760/cma.j.cn112434-20190130-00027
- VernacularTitle:亚临床甲减增加女性患者冠状动脉旁路移植术后呼吸道感染风险
- Author:
Hui ZHENG
1
;
Guoliang FAN
;
Baocheng CHANG
;
Huanqi GE
;
Chunfeng ZHANG
;
Xia GUO
Author Information
1. 国家卫生健康委员会激素与发育重点实验室 天津市代谢性疾病重点实验室 天津医科大学朱宪彝纪念医院 天津市内分泌研究所 300134；泰达国际心血管病医院内分泌科，天津 300457
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2020;36(5):284-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of subclinical hypothyroidism(SCH) on complications after coronary artery bypass grafting(CABG).Methods:The data of CABG patients hospitalized in TEDA International Cardiovascular Disease Hospital from January 2016 to December 2017 were retrospectively analyzed. According to the thyroid function after admission, the patients were divided into normal thyroid function group(NC group, 814 cases, 0.27 mIU/L≤TSH≤4.2 mIU/L) and subclinical hypothyroidism group(SCH group, 106 cases, TSH>4.2 mIU/L). The preoperative clinical data, surgical conditions, recent complications and one-year bridge stenosis rate were compared between the two groups in male or female.Results:Compared with NC group, SCH group had more female patients(53.8% vs 24.4%, P=0.000), lower smoking rate (38.7% vs 58.0%, P=0.000). There was no statistical difference in other baseline data and postoperative complications( P>0.05). Subgroup analysis depending on gender showed that the incidence of respiratory tract infection increased in female patients with SCH(10.5% vs 3.5%, P=0.034) compared with those in NC group, there was no significant difference in male. The TSH level was an independent risk factor for respiratory tract infection in female patients( OR=1.307, 95% CI=1.110-1.539, P=0.001). Compared with the male patients, the prevalence of hypertension(84.2% vs. 67.3%, P=0.041), diabetes mellitus(45.6% vs 16.3%, P=0.001), hospitalization time in ICU(44 h vs. 42 h, P=0.003), acute renal failure(10.5% vs 0, P=0.019) and massive blood transfusion(8.8% vs 0, P=0.034)increased. Conclusion:SCH appears to influence the postoperative outcome for female patients by increasing the development of postoperative respiratory tract infection.
