Acute Myeloid Leukemia with t(8;21)(q22;q22) (AML1/ETO) in a Patient with Marked Hypocellularity and Low Blasts Count.
10.12701/yujm.2007.24.1.85
- Author:
Sung Ho CHUN
;
Hee Soon CHO
;
Chae Hoon LEE
;
Kyung Dong KIM
;
Min Kyoung KIM
;
Myung Soo HYUN
;
Soon Il JUNG
- Publication Type:Case Report
- Keywords:
Acute myeloid leukemia;
t(8;
21)(q22;
q22);
Hypocellularity
- MeSH:
Bone Marrow;
Bone Marrow Transplantation;
Classification;
Drug Therapy;
Humans;
Leukemia;
Leukemia, Myeloid, Acute*;
Prognosis;
World Health Organization
- From:Yeungnam University Journal of Medicine
2007;24(1):85-90
- CountryRepublic of Korea
- Language:English
-
Abstract:
According to the World Health Organization (WHO) classification system, cases with t(8;21)(q22;q22) should be diagnosed as acute myeloid leukemia (AML) even with a blast count of less than 20 percent in blood or bone marrow. It is an uncommon manifestation, moreover hypocellularity is rarely observed in this subtype of leukemia. Here, we report a case of t(8;21) in a patient with marked hypocellularity of less than 5 percent and a blast count of less than 20 percent. This patient responded relatively well to chemotherapy. An allogeneic bone marrow transplantation was performed with good engraftment . This case suggests that hypocellular AML with a t(8;21) has as good a prognosis as hypercellular AML with t(8;21).
