Impact of interstitial lung disease on postoperative morbidity and 60 day mortality after pulmonary resection for lung cancer
10.3760/cma.j.cn112434-20190818-00273
- VernacularTitle:肺癌合并间质性肺病的手术治疗及术后60天病死率分析
- Author:
Weipeng SHAO
1
;
Jingjing HUANG
;
Jun ZHANG
;
Shanwu MA
;
Hongxiang FENG
;
Hongliang SUN
;
Yanhong REN
;
Xiaowei WANG
;
Zhenrong ZHANG
;
Deruo LIU
Author Information
1. 北京大学中日友好临床医学院 100029；中日友好医院胸外科，北京 100029
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2020;36(3):140-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of interstitial lung disease(ILD) on postoperative morbidity and mortality in pulmonary resection for lung cancer patients.Methods:We retrospectively analyzed 971 patients undergoing pulmonary operation from January 2010 to January 2018 in our hospital. Clinical data including age, sex, history of chronic obstructive pulmonary disease(COPD), smoking history, smoking index, American Society of Anesthesiologists(ASA) classification, forced expiratory volume in 1 s(FEV1) % predict, surgical procedure, video assisted thoracoscopic surgery(VATS) or not, intraoperative blood transfusion, anesthesia time, operation time/one-lung ventilation time, blood loss, histology, postoperative morbidity, 60-days mortality, onset of acute exacerbation of interstitial lung disease(AE-ILD), drainage, extubation time, and postoperative stay were collected and analyzed.Results:There were 80(8.2%) and 891(91.8%) patients in ILD and non-ILD group, respectively. AE-ILD occurred in 5 patients, with a 60-day mortality of 80%. A multivariate regression analysis identified that the sex( P=0.023), ILD( P=0.001), COPD( P=0.027) were independent risk factors for postoperative morbidity. ILD( P=0.023) and postoperative morbidity( P=0.001) were independent risk factors for 60-day mortality in multivariate analysis. Conclusion:Patients with ILD had a higher incidence of postoperative morbidity and 60-day mortality. Based on the obvious postoperative morbidity and mortality, special attention and management should be taken in ILD patients.
