Lung protection of remote limb ischemic preconditioning after pulmonary resection
10.3760/cma.j.cn112434-20190618-00206
- VernacularTitle:肢体远端缺血预处理对肺叶切除术患者的肺保护作用
- Author:
Maimaiti TUERXUNAYI·
1
;
Aimaiti ABULIKEMU·
;
Ning MA
;
Jiarong XU
;
Jiazheng XU
;
Haiping MA
Author Information
1. 新疆医科大学第一附属医院麻醉科，乌鲁木齐 830054
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2020;36(3):151-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate lung protection of remote limb ischemic preconditioning after pulmonary resection.Methods:Methods sixty adult patients scheduled for elective pulmonary resection, were randomly divided into control group(group C, 30 cases) and remote limb ischemic preconditioning(group RLIP, 30 cases) using a random number table. Before one-lung-ventilation(T0), at 30 minites, 1 hour and 2 hours of OLV(T1, 2, 3), 15minites after re-expansion of the collapsed lung(T4), blood samples were drawn from the radial artery and vein for blood gas analysis, alveolar-arterial oxygen gradient(A-aDO 2)、pulmonary shunt ratio(Qs/Qt)were calculated. Extraction time of closed thoracic drainage tube, length of hospital stay, the incidence of in-hospital complications after operation were recorded. Results:Compared to T0 , each group at T1-T4, A-aDO 2 were obviously increased. We found that at T3, A-aDO 2 of group C increased much more higher and statistically significant( P<0.05). Compared to group RLIP, Qs /Qt of group C were significantly increased at T2( P<0.05). Compared with C group, the expression of microtubule-associated protein 1 light chain 3B in lung tissues was significantly"up-regulated in RLIP group( P<0.05). Followed the extraction time of closed thoracic drainage tube, length of hospital stay, the incidence of in-hospital complications after operation there were no statistically different( P>0.05). Conclusion:Remote limb ischemic preconditioning had some protective effect after pulmonary resection, which mechanism may be related to enhancing autophagy in the operated 1ung tissues of the patients.
