Prophylactic value of budesonide viscous suspension for extensive esophageal stenosis after endoscopic submucosal dissection
10.3760/cma.j.cn321463-20191229-00588
- VernacularTitle:布地奈德凝胶预防食管内镜黏膜下剥离术后大面积狭窄的价值
- Author:
Jiaqing HU
1
;
Xiaolu LIN
;
Jiayao ZHENG
;
Yahua CHEN
;
Wanyin DENG
;
Xiaoling ZHENG
;
Xianbin GUO
;
Wei LIANG
Author Information
1. 福建省立医院消化内镜中心，福州 350000；福建医科大学研究生院，福州 350000
- From:
Chinese Journal of Digestive Endoscopy
2020;37(7):471-475
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of budesonide viscous suspension (BVS) in preventing extensive esophageal stenosis after endoscopic submucosal dissection(ESD).Methods:Data of 62 cases of early esophageal neoplasms or precancerous lesions receiving ESD whose postoperative mucosal defects were more than half the circumference of the esophageal lumen at Fujian Provincial Hospital from October 2014 to December 2018 were retrospectively studied. The patients were divided into the BVS group who received BVS therapy (n=24) and the control group who received no intervention (n=38). The incidence of postoperative stenosis, the number of bougie dilation procedures and complications were compared between the two groups. Risk factors for postoperative stricture were analyzed by logistic regression.Results:The incidence of postoperative stenosis [16.7% (4/24) VS 47.3% (18/38), P=0.005], the number of bougie dilation procedures (1.50±0.58 VS 2.70±1.09, P=0.039) in the BVS group were significantly lower than those in the control group. No serious adverse events such as perforation or massive hemorrhage related to BVS were observed in the BVS group. Multivariate logistic regression analysis showed circumferential extension ≥3/4 ( OR=37.970, 95% CI: 6.338-227.482) and non-intervention with BVS( OR=20.962, 95% CI: 3.374-130.243) were the independent risk factors for esophageal stricture after ESD. Conclusion:Administration of BVS is an effective and safe method to reduce the incidence of stenosis and the number of bougie dilation procedures for extensive esophageal stenosis after ESD.
