Advances in human skin microecology and microbiome in atopic dermatitis
10.3760/cma.j.cn112309-20200603-00289
- VernacularTitle:特应性皮炎的皮肤微生态和微生物组学研究进展
- Author:
Ying LIN
1
;
Haimin LUO
;
Minling ZHENG
;
Wenjun LI
;
Pinghua QU
Author Information
1. 广东省中医院大学城医院皮肤科，广州 510006；广州中医药大学第二临床医学院 510006；广东省中医药防治难治性慢病重点实验室，广州 510120
- From:
Chinese Journal of Microbiology and Immunology
2020;40(10):800-806
- CountryChina
- Language:Chinese
-
Abstract:
Atopic dermatitis (AD) is a chronic, relapsable and pruritic skin disease, commonly found in children and adolescents. The prevalence of AD is increasing worldwide. It is reported that AD is related to many factors such as genetic inheritance, environment, immunity and skin barrier dysfunction, suggesting a very complex pathogenesis. In recent years, high-throughput technologies in the field of genomics and metabolomics have opened up new perspectives on the pathogenesis of AD, and shown potential application prospects in microbiome transplantation therapies for AD. This review summarized the current advances in the relationship between skin microecology and skin health, the pathogenesis and microbiomic characteristics of AD, features of pathogenic microorganisms, and microbiome transplantation therapies for AD. Based on our own practical experience, we put forward a culturomics research protocol to study the human skin microbiome and a method for quantitative microbiological examination, aiming to provide reference for the prevention, clinical treatment and therapeutic monitoring of AD.
