HIV-1 genotypes and drug resistance among newly diagnosed young students in Nanjing
10.3760/cma.j.cn112309-20200228-00085
- VernacularTitle:南京市新诊断青年学生HIV-1亚型和耐药分析
- Author:
Jinjin CHU
1
;
Zhengping ZHU
;
Sushu WU
;
Xiaoshan LI
;
Wei LI
;
Pingmin WEI
Author Information
1. 东南大学公共卫生学院流行病与卫生统计学系，南京 230009
- From:
Chinese Journal of Microbiology and Immunology
2020;40(8):616-621
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate HIV-1 genotypes and drug resistance among newly diagnosed young students in Nanjing in order to provide reference for the prevention and control of AIDS in this group.Methods:This study enrolled 200 newly diagnosed young students with HIV-1 infection in Nanjing from September 2015 to July 2019. Demographic information and blood samples were collected. Through RNA extraction and PCR amplification, 191 pol fragments were successfully obtained and subjected to genotyping and drug resistance analysis. Results:CRF01_AE (41.4%) and CRF07_BC (30.9%) were the predominant genotypes, followed by unique recombinant forms (URFs) (15.7%), CRF55_01B (5.2%), CRF68_01B (3.1%), CRF67_01B (2.6%), and subtype B (1.0 %). The incidence of drug-resistant mutations was 16.8%, and the rate of transmitted drug resistance (TDR) was 4.2%. The rates of TDR in CRF01_AE, CRF07_BC, CRF55_01B, URFs and other genotypes were 2.5%, 1.7%, 10.0%, 10.0% and 7.7%, respectively ( P>0.05). Conclusions:The rapid emergence of recombinant HIV-1 strains in the young students should be taken seriously. The prevalence of TDR was close to the alert level, thus needing to be monitored continuously.
