Host NK-DC crosstalk in response to viral infection
10.3760/cma.j.cn112309-20191225-00435
- VernacularTitle:宿主NK-DC细胞相互作用与病毒感染
- Author:
Yanli CHEN
1
;
Longding LIU
Author Information
1. 中国医学科学院北京协和医学院医学生物学研究所，云南省重大传染病疫苗研发重点实验室，昆明 650118
- From:
Chinese Journal of Microbiology and Immunology
2020;40(6):477-483
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of interactions between natural killer (NK) cells and dendritic cells (DCs) in regulating the early stage of innate immune response and the subsequent adaptive immune response has been elucidated in recent years. NK-DC interactions result in the activation of NK cells and the maturation and/or apoptosis of DCs through direct cell-to-cell contact and releasing cytokines. NK cells can control and enhance DC-mediated antiviral immune response by inducing DCs to mature in favor of Th1 immune response and providing antigens to DCs and killing immature DCs (iDCs). DCs stimulate NK cells through soluble and cell-contact activators, thereby increasing their proliferation, survival and cytotoxicity to shape the innate immune response. Recent studies have shown that interactions between NK cells and DCs also play a critical role in several antiviral responses. Therefore, this paper reviewed the NK-DC interactions and their relationship with antiviral responses, thus providing a theoretical basis for studying the molecular mechanism of NK-DC interactions in viral infectious diseases.
