Dual effects of immune responses during highly pathogenic coronavirus infections and implications for novel coronavirus vaccine research and development
10.3760/cma.j.cn112309-20200420-00211
- VernacularTitle:免疫应答在高致病性冠状病毒感染中的双重作用及其对新型疫苗研究的启示
- Author:
Ziyu WEN
1
;
Yanjun LI
;
Musha CHEN
;
Caijun SUN
Author Information
1. 中山大学公共卫生学院(深圳)，广州 510006
- From:
Chinese Journal of Microbiology and Immunology
2020;40(6):410-417
- CountryChina
- Language:Chinese
-
Abstract:
The outbreaks caused by coronavirus (CoV) infections including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and COVID-19 have emerged in recent years, posing a continued threat to public health. Highly pathogenic CoV infections usually induce a series of immune responses, including innate immunity, humoral immunity, cellular immunity and mucosal immunity. These responses not only are critical to suppressing and eliminating the invasion of viruses, but also play an important role in immunopathological changes and disease progression. A deep understanding of the dual roles of immune responses will help to elucidate the pathogenic mechanism of CoV and maintain the balance between immune protection and immunopathology, which will be conducive to the research and development of safe and effective CoV vaccines. This review summarized the dual roles of immune responses in highly pathogenic CoV infections and discussed the implications for the research and development of novel CoV vaccines.
