Advances in the etiology of COVID-19
10.3760/cma.j.cn112309-20200312-00115
- VernacularTitle:新型冠状病毒肺炎的病原学研究进展
- Author:
Kai CHEN
1
;
Suwen JIANG
;
Airong HU
Author Information
1. 中国科学院大学宁波华美医院，宁波市肝病研究所 315010；宁波大学医学院研究生部 315211
- From:
Chinese Journal of Microbiology and Immunology
2020;40(4):256-261
- CountryChina
- Language:Chinese
-
Abstract:
In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the outbreak of COVID-19 in Wuhan. It is a kind of enveloped positive-strand RNA virus, belonging to the subgenus Sarbecovirus of the genus Betacoronavirus. It is similar to other viruses of the subgenus Sarbecovirus in genomic structure and closely related to the bat coronavirus (RaTG13), indicating that its natural host is likely to be bat, but the intermediate host is still controversial. SARS-CoV-2 infects host cells with angiotensin-converting enzyme 2 (ACE2) as a receptor. At present, SARS-CoV-2 has undergone some mutations. This article reviewed the current research situation and progress in the etiology of COVID-19.
