Progress in mucosal immune of female reproductive tract
10.3760/cma.j.cn112309-20190710-00211
- VernacularTitle:女性生殖道黏膜免疫进展
- Author:
Huihui WANG
1
;
Wenhui QI
;
Xingshuo LI
;
Aiping FAN
;
Cha HAN
;
Fengxia XUE
Author Information
1. 天津医科大学总医院妇产科 300052
- From:
Chinese Journal of Microbiology and Immunology
2020;40(3):238-243
- CountryChina
- Language:Chinese
-
Abstract:
The mucosal immune system is the first line of defense against pathogens such as bacteria and viruses invading the bodies. The female reproductive tract mucosal immune system not only resists the invasion of pathogens through innate and adaptive immunity, but also contribute to successfully fertilization and pregnancy, thus maintaining the health of women′s reproductive system. The innate immunity of female genital tract involves the mechanical barrier of the mucosal epithelium, microbial barrier of commensal bacteria, immunological barrier of immune cells and their receptors, and adaptive immunity including B cell-mediated humoral immunity and T cell-mediated cellular immunity. Female genital mucosal immunity is not only involved in local inflammation, but may also have anti-tumor effects. Moreover, the female genital tract mucosal immune is also regulated by sex hormone to maintain a homeostasis of local microenvironment. Herein, this paper summarized recent progress in female genital mucosal immunity.
