Progress in cross-species transmission of human coronaviruses (HCoVs)
10.3760/cma.j.cn112309-20200209-00054
- VernacularTitle:人冠状病毒跨种传播的研究进展
- Author:
Yanwei CHENG
1
;
Xue CAO
;
Lijie QIN
Author Information
1. 河南省人民医院急诊科，郑州大学人民医院，河南大学人民医院，郑州 450000
- From:
Chinese Journal of Microbiology and Immunology
2020;40(2):146-153
- CountryChina
- Language:Chinese
-
Abstract:
Coronaviruses (CoVs) are a group of ancient and common viruses, posing a severe threat to the health of humans and other animals. Currently, seven human CoVs (HCoVs) have been identified. They are all animal-derived zoonotic pathogens that jump the species barrier from their natural host animals to humans in a direct or indirect manner and lead to interpersonal transmission. The receptor binding domain (RBD) on the S1 subunit of CoV spike (S) protein is one of the key factors determining the cross-species transmission and the invasion potential. This review summarized and analyzed the transmission modes of seven HCoVs and the available structures of HCoV-RBD that mediated the cross-species transmission in order to better understanding the mechanism of CoV cross-species transmission and providing valuable knowledge in response to the potential cross-species transmission of novel CoVs in the future.
