The effect of environment on the serum concentrations of adrenocorticotropic hormone, cortisol and testosterone
10.3760/cma.j.issn.0254-1424.2020.11.003
- VernacularTitle:环境对雄性快速老化小鼠P8血促肾上腺皮质激素、皮质醇与睾酮浓度的影响
- Author:
Huimin QIAO
1
;
Haiyan ZHAN
;
Bingjie WU
;
Mei DONG
;
Fan XUE
;
Rui YANG
Author Information
1. 河北医科大学第二医院东院区神经内科，石家庄 050000
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2020;42(11):973-977
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate any effect of different environments on the levels of adrenocorticotropic hormone (ACTH), cortisol and testosterone using SAMP8 senescence-accelerated mice.Methods:Thirty SAMP8 mice were randomly divided into an enriched environment (EE) group, an impoverished environment (IE) group and a standard environment (SE) group, each of 10. The serum levels of ACTH, cortisol and testosterone were measured in all of the mice after they had lived in their respective environments for 8 weeks.Results:The average ACTH concentrations of the IE, EE and SE groups were (60.54±16.22), (48.98±15.30) and (28.49±8.24)pg/ml respectively. The average cortisol concentrations were (5.37±0.81), (4.09±0.92) and (3.19±0.88)ng/ml. The average testosterone concentrations being (2.35±0.90), (7.07±1.57) and (3.16±1.10)ng/ml. The average ACTH and cortisol levels were significantly different between the SE and IE groups. The average ACTH and testosterone levels differed significantly between the SE and EE groups and between the EE and IE groups.Conclusions:An impoverished environment can increase the secretion of ACTH and cortisol and activate the hypothalamic-pituitary-adrenal axis, at least in SAMP8 mice. An enriched environment can promote the secretion of ACTH and testosterone, but not that of cortisol.
