A clinical study of ultrasound-guided botulinum toxin A injection for treating sialorrhoea in children
10.3760/cma.j.issn.0254-1424.2020.11.008
- VernacularTitle:超声引导下不同剂量A型肉毒毒素注射治疗儿童流涎症的临床研究
- Author:
Sansong LI
1
;
Ruimin LIU
;
Jun WANG
;
Junying YUAN
;
Guangyu ZHANG
;
Lei YANG
;
Mingmei WANG
;
Guohui NIU
;
Hanyou LIU
;
Dengna ZHU
Author Information
1. 郑州大学第三附属医院，郑州 450052
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2020;42(11):995-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy and any side effects of using ultrasound-guided injection of botulinum toxin A in treating juvenile sialorrhoea.Methods:Forty children with sialorrhoea were randomly divided into group A and group B, each of 20. Under the guidance of color Doppler ultrasound, botulinum toxin type A (BoNT-A) was injected into the children′s 2 parotid glands and their submandibular glands. Each parotid gland was injected with 20u of BoNT-A, while 10u was injected into the submandibular gland in group A and 20u was injected in group B. Before and 2, 8 and 12 weeks after the injections, the children′s sialorrhoea was evaluated using teacher drooling sizing (TDS), the drooling quotient and the Saxon test (ST). Any side-effects were also observed.Results:There was no significant difference in the average TDS score, drooling quotient or ST score between the two groups before the intervention. After the intervention all of those measurements had decreased significantly, but there were still no significant differences between the two groups in any measurement at any time point.Conclusions:Botulinum toxin type A injection under the guidance of ultrasound is accurate and safe. The injection of 10u is sufficient to relieve children′s sialorrhoea without serious side effects.
