High-frequency repetitive transcranial magnetic stimulation can relieve mild amnestic cognitive impairment
10.3760/cma.j.issn.0254-1424.2020.06.005
- VernacularTitle:高频重复经颅磁刺激治疗遗忘型轻度认知障碍的局部一致性研究
- Author:
Fen ZHU
1
;
Liqiong YUAN
;
Dan WANG
;
Xiuyun WEN
;
Xiaomei ZHOU
;
Tingting TAN
;
Shangjie CHEN
;
Qing ZENG
;
Guozhi HUANG
Author Information
1. 南方医科大学深圳宝安医院康复医学科，深圳 518100
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2020;42(6):505-510
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the therapeutic mechanism of high-frequency repetitive transcranial magnetic stimulation (rTMS) in treating mild amnestic cognitive impairment (aMCI).Methods:Twenty-five patients with aMCI were randomly divided into an observation group of 13 and a control group of 12. The observation group was given 10-Hz rTMS over the left dorsolateral prefrontal cortex at 80% of the motor threshold-400 pulses a day, 5 times a week for 4 consecutive weeks. The control group received sham stimulation on the same schedule. Before and after the experiment, both groups were evaluated using the Montreal cognitive assessment (MoCA) and received fMRI scans.Results:After the intervention, the average MoCA score of the observation group had improved significantly more compared with that of the control group and compared with before the intervention. According to the fMRI results, regional homogeneity in the right middle frontal gyrus of the observation group had increased significantly, while that of the control group both there and in the left precuneus had decreased significantly.Conclusions:High-frequency rTMS can effectively improve the cognitive function of patients with aMCI and synchronize neuron activity in cognition-related brain regions.
