The efficacy of repetitive transcranial magnetic stimulation in the treatment of mild cognitive impairment: A meta-analysis
10.3760/cma.j.issn.0254-1424.2020.06.020
- VernacularTitle:重复经颅磁刺激治疗轻度认知障碍疗效的Meta分析
- Author:
Liang ZHOU
1
;
Zhiwei GUO
;
Binghu JIANG
;
Mengjie CAI
;
Linzi QIN
;
Yonghui DU
;
Xi BAI
;
Qiwen MU
Author Information
1. 川北医学院第二临床医学院南充市中心医院影像科，南充 637000；湖北省荆州市中心医院放射科，荆州 434020
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2020;42(6):562-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the cognition of patients with mild cognitive impairment (MCI).Methods:The PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang, and VIP databases were searched for randomized controlled trials of rTMS treating MCI patients before March 2019. After screening the literature, extracting the data and two independent reviewers evaluating the quality of the included studies, the meta-analysis was conducted using version 5.3 of the RevMan software.Results:Nine studies covering 368 patients were included. The pooled results showed that compared with sham stimulation, rTMS treatment could effectively improve the cognitive ability (assessed using the Montreal instrument), episodic memory, verbal fluency and the amplitude of MCI patients′ P300 signals. P300 latency was also reduced. However, there was no significant difference, on average, in memory quotient or P300 latency between patients given rTMS plus donepezil hydrochloride and those given donepezil hydrochloride alone. Compared with the control groups, the rTMS treatment groups displayed slightly more frequent adverse reactions, mainly mild dizziness and scalp pain which disappeared within 1-2 hours without obvious residual effects.Conclusions:TMS treatment can effectively improve cognitive and memory function.
