Spontaneous rupture and massive hemorrhage of tuberous sclerosis-related renal hamartoma in a pregnant woman in third trimester: a case report
10.3760/cma.j.cn113903-20200212-00096
- VernacularTitle:妊娠合并结节性硬化症相关肾错构瘤孕晚期自发性破裂大出血一例
- Author:
Cuilian LIU
1
;
Runfang WANG
;
Sisi LI
;
Xiaoqian YIN
;
Yan HUO
Author Information
1. 河北省人民医院产科，石家庄 050000
- From:
Chinese Journal of Perinatal Medicine
2020;23(11):774-777
- CountryChina
- Language:Chinese
-
Abstract:
The diagnosis and treatment of spontaneous rupture and massive hemorrhage of tuberous sclerosis-related renal hamartoma in a woman in the third trimester are reported. The patient was admitted at 39 weeks of gestation, with threatened labor and a history of bilateral renal hamartoma, which had been hidden. Placental abruption was considered due to persistent lumbago, abdominal pain, abdominal muscle tension, uterine tension and fetal heart rate dropping to 90 bpm, and an emergency cesarean section was performed at 39 +1 weeks. About 200 ml of bloody ascites was found in the peritoneal cavity. A live boy was delivered and no blood clot was seen in the maternal face of the placenta. After the uterine incision was closed, a huge bluish purple mass was detected on the right-side retroperitoneum and the renal angiography showed rupture and hemorrhage of a right renal hamartoma. A selective right renal artery embolization was performed. The patient recovered after the operation and was discharged seven days later required by the family. The patient was in good condition except for hematuria during a 30-day postpartum follow-up, and oral everolimus treatment and regular follow-up were continued. The newborn with a birth weight of 2 355 g was transferred to the neonatology department after birth due to severe asphyxia, and postnatal echocardiography suspected heart rhabdomyoma. The baby had one seizure but was otherwise well, and was discharged after eight days. The seizure did not recur to the neonate after discharge. Clinicians should pay attention to pregnant women with renal hamartoma. If abnormal abdominal distension, hematuria or lumbago occur during pregnancy, rupture of renal hamartoma and possible massive hemorrhage should be considered.
