Brain-derived neurotrophic factor in neonatal hypoxic-ischemic encephalopathy: a review
10.3760/cma.j.cn113903-20200807-00748
- VernacularTitle:脑源性神经营养因子在新生儿缺氧缺血性脑病中的作用研究进展
- Author:
Chunlin ZHAO
1
;
Yanhong YANG
;
Hailan YANG
Author Information
1. 山西医科大学附属第一医院产科，太原 030000
- From:
Chinese Journal of Perinatal Medicine
2020;23(10):690-694
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal mortality and neurologic sequelae. Current evidence showed that the brain-derived neurotrophic factor (BDNF) could be considered as a specific biomarker of brain injury, which could help to assess the severity and prognosis of neonatal HIE. Also, BDNF may be widely applied in clinical practice to monitor the treatment of neonatal HIE due to its important role in neuronal survival and growth. This paper summarizes the possible role of BDNF in the management of HIE from these aspects.
