Role of T cell immunoglobulin domain and mucin domain-3 and galectin-9 pathway in maintaining pregnancy immune tolerance
10.3760/cma.j.cn113903-20200118-00032
- VernacularTitle:T细胞免疫球蛋白黏蛋白分子-3-半乳糖凝集素-9通路维持妊娠免疫耐受的作用
- Author:
Yan YANG
1
;
Min JIANG
;
Xueqiong LIU
;
Dan LU
Author Information
1. 大连医科大学研究生院 116044
- From:
Chinese Journal of Perinatal Medicine
2020;23(8):561-564
- CountryChina
- Language:Chinese
-
Abstract:
Galectin-9 (Gal-9) is a member of the lectin family expressed in NK cells, dendritic cells, macrophages, T helper cells, regulatory T cells, etc. T cell immunoglobulin domain and mucin domain-3 (Tim-3) interact with ligand Gal-9 mediating different immune regulatory effects in different immune cells. This Tim-3/Gal-9 pathway is associated with various conditions, such as autoimmune diseases, tumors, virus infections, and pregnancy-related diseases. This paper reviews the role of the Tim-3/Gal-9 pathway in maintaining immune tolerance in pregnancy by regulating innate and adaptive immune responses and its potential as a new target for immunotherapy in pregnancy-related diseases.
