A model for predicting cesarean delivery in term low-risk primipara after failure of trial of labor
10.3760/cma.j.cn113903-20191023-00605
- VernacularTitle:足月妊娠低风险初产妇阴道试产失败中转剖宫产预测模型的建立
- Author:
Fangcan SUN
1
;
Fangfang WU
;
Minhong SHEN
;
Bing HAN
Author Information
1. 苏州大学附属第一医院妇产科 215006
- From:
Chinese Journal of Perinatal Medicine
2020;23(7):460-468
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a model for predicting cesarean delivery after failure of trial of labor among low-risk term primipara.Methods:This study retrospectively analyzed the clinical data of low-risk primiparas, with singleton cephalic full-term fetus, who delivered in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Soochow University from January 1, 2011 to August 31, 2017. Women experienced cesarean delivery(CS) following failed trial of labor were grouped as CS group, while those successfully delivered normally as vaginal delivery group(VD group). Chi-square test, t-test and multivariate logistic regression analysis were used for statistical analysis. Influencing factors of CS after a failed trial of labor were screened to establish the prediction model. The area under the receiver operating characteristic curve (AUC) and Hosmer-Lemeshow goodness-of-fit test were used to assess the performance of the model. A nomogram was established using R programming language based on the predictive model. Results:(1) This study recruited 6 551 subjects and among them, 576 (8.8%) women experienced CS after a failed trial of labor and the rest 5 975(91.2%) delivered vaginally. (2) The women in CS group were older [(27.5±3.1) vs (26.8±3.0) years, t=-4.963, P<0.01] and shorter in height [(159.5±4.2) vs (161.7±4.6) cm, t=11.548, P<0.01] , had higher pre-pregnancy body mass index (BMI) [(21.5±2.6) vs (20.8±2.5) kg/m 2, t=-6.743, P<0.01] and higher weight gain during pregnancy [(14.8±4.2) vs (14.1±4.2) kg, t=-3.446, P<0.01] and delivered later [(282±7) vs (278±7) d, t=-10.499, P<0.01] compared with those in VD group. The incidence of premature rupture of membranes (PROM) [26.4% (152/576) vs 20.7% (1 238/5 975) , χ2=10.101, P<0.01], labor induction [oxytocin: 26.4% (152/576) vs 16.3% (976/5 975), artificial rupture of membranes: 46.5% (268/576) vs 36.6% (2 189/5 975), application of cervical dilator balloon: 2.6% (15/576) vs 1.1% (65/5 975) and Propess: 4.7% (27/576) vs 2.5% (149/5 975), χ2=134.918, P<0.01], and the proportion of cases with meconium-stained amniotic fluid [ Ⅰ: 5.2% (30/576) vs 3.5% (209/5 975), Ⅱ: 5.7% (33/576) vs 2.5% (150/5 975), Ⅲ/bloody: 13.7% (79/576) vs 1.8% (105/5 975), χ2=307.664, P<0.01] were all higher in CS group than in VD group. There were more male infants [58.0% (334/576) vs 49.1% (2 934/5 975), χ2=16.576, P<0.01] and higher neonatal birth weight [(3 528±389) vs (3 344±368) g, t=-11.431, P<0.01] in the CS group as well. (3) Multivariate logistic regression analysis showed that maternal age and height, pre-pregnancy BMI, weight gain during pregnancy, gestational age at delivery, PROM, labor induction with oxytocin, artificial rupture of membrane, application of cervical dilator balloon and Propess, meconium-stained amniotic fluid, and fetal gender were all independent factors for CS. Two prediction models and nomograms were established according to fetal gender was involved or not. (4) The AUC of the prediction model not involving fetal gender was 0.774 (95% CI: 0.763-0.784) and the cut-off value was >8.7% with the sensitivity and specificity of 0.707 and 0.706, while that involving fetal gender was 0.782 (95% CI: 0.771-0.791) with the sensitivity and specificity of 0.785 and 0.645, respectively, when the cut-off value was >7.4%. The Hosmer-Lemeshow goodness-of-fit test showed that the two models fitted well (both P>0.05). Results of the internal validation using Bootstrap method indicated that the CS rates predicted by both models were consistent with the real data. Conclusions:The established models could effectively and accurately predict CS in term, singleton, cephalic, and low-risk primipara after failure of trial of labor, which might be a tool for clinicians to inform pregnant women to choose an appropriate delivery mode, thus improving maternal and infant outcomes.
