Progress in fetal and neonatal alloimmune thrombocytopenia
10.3760/cma.j.cn113903-20190318-00179
- VernacularTitle:胎儿及新生儿同种免疫性血小板减少症研究进展
- Author:
Yuanjun WU
1
;
Fubing YU
;
Yongmei ZHANG
;
Bingmei DAI
;
Yong YANG
Author Information
1. 东莞市妇幼保健院输血科 523120
- From:
Chinese Journal of Perinatal Medicine
2020;23(5):348-353
- CountryChina
- Language:Chinese
-
Abstract:
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) occurs when fetal platelets are sensitized and then phagocytized by macrophages in the reticuloendothelial system after antibodies specific for allogeneic platelets in the pregnant women cross the placenta and enter the fetus. In severe cases, intracranial hemorrhage and even fetal death may occur. This article reviews the recent progress in the following aspects: the mechanisms of pregnancy-related platelet alloimmunity, platelet destruction mechanisms in FNAIT, correlation of anti-angiogenic effects and intracranial hemorrhage, correlation between anti-GPIbα antibodies and miscarriage, and the diagnosis, treatment and prevention of FNAIT.
