A healthy neonate born at the third pregnancy of a woman with ornithine carbamoyltransferase deficiency under multidisciplinary management
10.3760/cma.j.issn.1007-9408.2020.02.007
- VernacularTitle:多学科管理下鸟氨酸氨甲酰基转移酶缺乏症妇女连续三次妊娠分娩健康儿一例
- Author:
Yah ZENG
1
;
Yuelin WU
;
Huaxiang SHEN
;
YangMengnan
;
Shengyi GU
;
Zhengqian MOU
;
Xiaolin HUA
Author Information
1. 上海交通大学医学院附属新华医院妇产科 200092
- Keywords:
Ornithine carbamoyltransferase deficiency disease;
Gravidity;
Peripartum period;
Patient care management
- From:
Chinese Journal of Perinatal Medicine
2020;23(2):111-113
- CountryChina
- Language:Chinese
-
Abstract:
We reported a women with omithine carbamoyltransferase deficiency who delivered a healthy boy after two pregnancies with adverse outcome with the help of a multidiscipline team.The woman was admitted to Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine with an acute prenatal hyperammonemic episode at 28 gestational weeks of her first pregnancy in 2013 and was diagnosed with ornithine transcarbamylase deficiency.Her hyperammonemic complications were controlled under a well-planned multidisciplinary management including a low-protein diet and appropriate medications assisting nitrogen removal.A boy was delivered by cesarean section at 32 weeks of gestation but died three days later.Mutation analysis revealed a hemizygous c.583G＞A (G195R) mutation in the neonatal omithine carbamyltransferase gene and his mother was a heterozygous carrier with the same mutation.Two years later in 2015,the patient was pregnant spontaneously.However,she received an induced abortion at 21 weeks of gestation because amniocentesis and DNA analysis showed that the male fetus had the same omithine transcarbamylase gene mutation.The index pregnancy was assisted by in vitro fertilization-embryo transfer and preimplantation genetic diagnosis in 2017 and the woman delivered a healthy boy with the management ofa multidisciplinary team.
