Comparison of cognitive function between patients with hemodialysis and peritoneal dialysis
10.3760/cma.j.cn441217-20200303-00119
- VernacularTitle:维持性血液透析与腹膜透析患者认知功能障碍的比较
- Author:
Yujun QIAN
1
;
Jianping YANG
;
Bo HOU
;
Hui YOU
;
Fei HAN
;
Jing YUAN
;
Yicheng ZHU
;
Feng FENG
;
Ke ZHENG
;
Limeng CHEN
;
Xuemei LI
Author Information
1. 中国医学科学院，北京协和医学院，北京协和医院肾内科，北京 100730
- From:
Chinese Journal of Nephrology
2020;36(9):657-665
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate whether dialysis modality will affect cognitive function in dialysis population.Methods:This was a cross-sectional study. Chronic dialysis patients in our center was screened from July 2013 to July 2014. All of the subjects received brain magnetic resonance imaging (MRI) examination and comprehensive cognitive function evaluation.Results:A total of 189 chronic dialysis patients were enrolled in this study, 122 cases on hemodialysis (HD) and 67 cases on peritoneal dialysis (PD). There was no significant difference in age between HD and PD groups [(56.4±13.2) years vs (56.4±16.1) years, t=0.004, P=0.997]. The dialysis vintage and serum albumin of HD patients was higher than those of PD patients[58.0(16.8, 107.5) months vs 31.0(7.0, 67.0) months, Z=-3.490, P<0.001; (39.6±3.9) g/L vs (35.3±3.8) g/L, t=7.328, P<0.001, respectively]. The prevalence of cerebral small vessel diseases (CSVDs) was comparable between HD and PD groups (all P>0.05). Compared with HD patients, PD patients presented a 11.90-fold risk of immediate memory impairment (95% CI 1.40-101.08, P=0.023) and a 6.18-fold risk of long-delayed memory impairment (95% CI 2.12-18.05, P=0.001). After adjusting for age, educational lever, dialysis vintage, serum creatinine, and CSVDs, the influence of dialysis modality on memory still worked. PD patients presented a 43% risk of executive function impairment of HD patients ( OR=0.43, 95% CI 0.17-1.04, P=0.061). Conclusions:HD patients manifested better memory than PD patients, while PD probably performed better in executive function than HD patients. There was no significant difference in language function between the two groups. The difference in cognitive function may not be related to CSVDs.
