Advances of muscular atrophy and denervation after stroke
10.3760/cma.j.cn113694-20200325-00207
- VernacularTitle:脑卒中后瘫痪肢体肌肉萎缩和失神经支配研究进展
- Author:
Zimu JIANG
1
;
Jiahui LIANG
;
Jianle LI
;
Chunyong CHEN
;
Pingping LI
;
Jiating WEI
;
Jinsheng ZENG
Author Information
1. 中山大学附属第一医院神经科，广东省重大神经疾病诊治研究重点实验室，广州 510080
- From:
Chinese Journal of Neurology
2020;53(12):1063-1067
- CountryChina
- Language:Chinese
-
Abstract:
It was generally believed that muscular atrophy of paralyzed limbs after stroke was due to disuse. However, recent studies have found that secondary lesions of motor neurons in the contralateral anterior horn of the spinal cord and the decrease of motor units lead to denervation, which plays an essential role in muscular atrophy and muscle fiber type transition. This article reviews the phenomenon and mechanism of muscular atrophy and denervation of paralyzed limbs after stroke, to provide a reference for clinical evaluation and experimental research.
