Neurofilament and amyotrophic lateral sclerosis
10.3760/cma.j.cn113694-20200327-00213
- VernacularTitle:神经丝蛋白与肌萎缩侧索硬化
- Author:
Zhengyi CAI
1
;
Liying CUI
Author Information
1. 中国医学科学院北京协和医院神经科 100730
- From:
Chinese Journal of Neurology
2020;53(12):1055-1062
- CountryChina
- Language:Chinese
-
Abstract:
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, stimultaneously affecting cerebral pyramidal cells, motor nuclei in the brain stem, anterior horn cells of the spinal cord, and the pyramidal tract. The early diagnosis of ALS is very difficult. At present, it still lacks efficacious therapy. Its prognosis is poor, with the median survival time for about 3-5 years. The study and discovery of ALS-specific biomarkers for early diagnosis are critical to shorten diagnostic delay, explore and elucidate pathogenesis, monitor disease progression and predict prognosis. In recent years, studies have shown that the neurofilament plays an important role in the aspects above, and at present, it is considered as the most clinically valuable and promising biomarker for ALS. Thus, the article provides a review about research on neurofilament and ALS.
