Progress in clinical registration research of gene therapy for Parkinson′s disease
10.3760/cma.j.cn113694-20200512-00346
- VernacularTitle:帕金森病基因治疗临床注册研究进展
- Author:
Kaige ZHOU
1
;
Jingxing ZHANG
;
Lingjing JIN
Author Information
1. 同济大学附属同济医院神经内科，上海 200065
- From:
Chinese Journal of Neurology
2020;53(12):1051-1055
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease is a neurodegenerative disease characterized by bradykinesia, resting tremor, and hypermyotonia. Its pathological features are the loss of nigra dopamine neurons and the abnormal aggregation of α-synuclein, and there is currently no treatment that blocks the progression of the disease. Gene therapy, by increasing the expression of neurotrophic factors and increasing levels of neurotransmitters, may slow, terminate, or even reverse the progression of the disease, so it gets more attention. This article reviews the progress of registered clinical research on gene therapy for Parkinson′s disease.
