Research progress of neuromelanin and the pathogenesis of Parkinson′s disease
10.3760/cma.j.cn113694-20200217-00088
- VernacularTitle:神经黑色素与帕金森病发病机制的研究进展
- Author:
Lu WANG
1
;
Yayun YAN
;
Liyao ZHANG
;
Xiufeng LIU
;
Yan LIU
;
Ruirui LUO
;
Ying CHANG
Author Information
1. 吉林大学中日联谊医院神经内科，长春 130033
- From:
Chinese Journal of Neurology
2020;53(11):954-958
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease (PD) is a common neurodegenerative disease. Its main pathological feature is the progressive loss of substantia nigra and other catecholaminergic neurons containing neuromelanin (NM). Therefore, NM may be closely related to the pathogenesis of PD. The content of NM can be detected by NM magnetic sensitive sequence imaging, and then it can be applied to the study of the neuropathological mechanism of NM and PD. This paper focuses on the physiological significance of NM, its role in the pathogenesis of PD and the prospect of NM as a biomarker to assist diagnosis and disease monitoring of PD.
