Research progress on the role of mRNA N6-methyladenosine methylation in the nervous system
10.3760/cma.j.cn113694-20200420-00277
- VernacularTitle:mRNA N6-甲基腺苷甲基化在神经系统作用的研究进展
- Author:
Ran LI
1
;
Yanlei HAO
Author Information
1. 山东大学齐鲁医学院，济南 250100
- From:
Chinese Journal of Neurology
2020;53(10):819-823
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine (m 6A), one of the most common types of eukaryotic mRNA methylation modification, is widely distributed in the nervous system and participates in important regulatory mechanisms for controlling gene expression. With the participation of related methylation-modifying enzymes and proteins, m 6A plays an important role in the growth and development of the nervous system, related functions, and the occurrence and development of diseases in the nervous system by affecting the "life cycle" of mRNA. This article briefly reviews the research progress on the role of mRNA m 6A methylation modification in neurological diseases and nervous system growth and development.
