Association between cerebral blood hypoperfusion and cognitive impairment in patients with asymptomatic middle cerebral artery stenosis
10.3760/cma.j.cn113694-20191114-00713
- VernacularTitle:无症状性大脑中动脉狭窄患者脑血流低灌注与认知障碍
- Author:
Rui PAN
1
;
Na LIU
;
Long ZHANG
;
Dongqing LIU
;
Jianhua ZHAO
Author Information
1. 郑州大学人民医院，河南省人民医院神经内科 450003
- From:
Chinese Journal of Neurology
2020;53(8):598-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between cerebral hypoperfusion and cognitive function decline in patients with asymptomatic middle cerebral artery stenosis.Methods:Sixty patients with moderate or severe stenosis of middle cerebral artery were diagnosed by magnetic resonance angiography (MRA) in the Department of Neurology, Henan Provincial People′s Hospital from November 2017 to November 2018. All patients were divided into perfusion weighted imaging (PWI) normal group （ n=14）, PWI compensated group ( n=26) and PWI decompensated group ( n=20) according to the results of PWI of magnetic resonance imaging. All patients were assessed for cognitive function using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment scale (MoCA). Results:The cognitive scores of the PWI decompensated group (MMSE score: 19.35±3.26; MoCA score: 16.06±2.59) were significantly lower than the PWI normal group (MMSE score: 26.29±3.12; MoCA score: 24.27±2.85) and the PWI compensated group (MMSE score: 23.78±1.77; MoCA score: 20.69±2.73), and the differences were statistically significant ( F=5.257, 4.134; P<0.05). The visual space and executive ability, language, delayed recall in the PWI compensated group (3.27±0.97, 1.45±0.73, 2.47±1.73, respectively) and the PWI decompensated group (1.96±0.79, 0.97±0.59, 1.49±1.38, respectively) were significantly lower than those of the PWI normal group (4.25±1.29, 2.57±1.24, 3.57±1.51, respectively), and the differences were statistically significant ( F=6.371,5.394,4.989, P<0.05). Patients in the PWI decompensated group had atrophy in the narrow hemisphere. Conclusion:Low cerebral perfusion induced by asymptomatic moderate-to-severe stenosis of the middle cerebral artery is associated with extensive cognitive impairment and local brain atrophy.
