Pay attention to cognitive impairment in Parkinson′s disease
10.3760/cma.j.cn113694-20200108-00021
- VernacularTitle:重视帕金森病的认知障碍
- Author:
Fangzheng CHEN
1
;
Jun LIU
Author Information
1. 上海交通大学医学院附属瑞金医院神经内科 200025
- From:
Chinese Journal of Neurology
2020;53(7):481-484
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment is one of the most common non-motor symptoms of Parkinson′s disease, which is mainly related to abnormal protein deposition in related brain regions, impaired synaptic function, various transmitter system disorders and neuroimmune abnormalities. The incidence of Parkinson′s disease is relatively high, which seriously affects the quality of life of patients and imposes a heavy burden on society and families. At present, there are some early diagnostic markers in cerebrospinal fluid, peripheral fluid, gene and neuroimaging, which can be used for early warning and early recognition of cognitive impairment in Parkinson′s disease. Early warning and early diagnosis of cognitive impairment in Parkinson′s disease should be emphasized, and certain intervention and treatment can be carried out if necessary. Meanwhile, prospective, multicenter and large-sample high-quality clinical studies on cognitive impairment in Parkinson′s disease are needed urgently.
